Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages

IntroductionHypertension is a major risk factor for cardiovascular disease (CVD) and is associated with increased bone loss due to excessive activity of the local renin-angiotensin system (RAS). Angiotensinogen/Angiotensin (ANG) II/Angiotensin II type 1 receptor (AT1R) axis is considered as the core...

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發表在:	Frontiers in Endocrinology
Main Authors:	Ziqiu Fan, Hideki Kitaura, Jiayi Ren, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Kayoko Kanou, Mariko Miura, Kohei Narita, Angyi Lin, Itaru Mizoguchi
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2023-09-01
主題:	osteoclast azilsartan bone resorption TNF-α LPS Angiotensin II type 1 receptor blocker
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1207502/full