Class I HDAC Inhibitor Improves Synaptic Proteins and Repairs Cytoskeleton Through Regulating Synapse-Related Genes In vitro and In vivo

β-amyloid (Aβ) is an important protein molecule in the pathology of Alzheimer’s disease (AD). Accumulation of Aβ leads to the loss of dendritic spines and synapses. These impairments can be ameliorated by histone deacetylase inhibitors (HDACI). However, the mechanisms of HDACIs underlying the effect...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Ying Han, Le Chen, Yu Guo, Chunyang Wang, Chenghong Zhang, Li Kong, Haiying Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Subjects:	Alzheimer’s disease β-amyloid HDAC inhibitor synaptic protein cytoskeletal protein
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2020.619866/full