Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold

A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase XII (hCA XII) to synergistically overcome the P-gp-mediated multidrug resistance (MDR) in cancer cells expressing the two proteins, P-gp and h...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Laura Braconi, Chiara Riganti, Astrid Parenti, Marta Cecchi, Alessio Nocentini, Gianluca Bartolucci, Marta Menicatti, Marialessandra Contino, Nicola Antonio Colabufo, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran, Elisabetta Teodori
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	MDR reversers P-gp modulators CA XII inhibitors K562/DOX HT29/DOX A549/DOX
Online Access:	https://www.mdpi.com/1420-3049/29/14/3290