The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine — the supraspliceosome. It is composed of four splicing active native spliceosomes, each resembling an in vitro assembled spliceosome, which are connected by the pr...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Kinneret Shefer, Joseph Sperling, Ruth Sperling
Format:	Article
Language:	English
Published:	Elsevier 2014-09-01
Subjects:	Pre-mRNA splicing Riponucleoproteins (RNPs) U snRNPs Alternative splicing Intronic microRNA biogenesis Suppression of splicing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037014000348