PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses

Abstract VISA/MAVS is crucial in antiviral innate immunity. Upon RNA virus infection, VISA recruits TBK1 via TRAFs to mitochondria, inducing IRF3 phosphorylation and type I interferons. However, TBK1 recruitment mechanisms via individual TRAFs are unclear. Here, we reveal that PWWP domain-containing...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Mengling Shi, Cong Wang, Zhen Chen, Yidan Zhou, Liang Yue, Yu Liu, Tiannan Guo, Jun Shang, Haotian Xu, Yu Zhang, Mengcheng Luo, Caoqi Lei
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-59421-x