Depletion of tRNA CCA-adding enzyme in Mycobacterium tuberculosis leads to polyadenylation of transcripts and precursor tRNAs

Abstract In reference to gene annotation, more than half of the tRNA species synthesized by Mycobacterium tuberculosis require the enzymatic addition of the cytosine-cytosine-adenine (CCA) tail, which is indispensable for amino acid charging and tRNA functionality. It makes the mycobacterial CCA-add...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ewelina Błaszczyk, Przemysław Płociński, Ewelina Lechowicz, Anna Brzostek, Bożena Dziadek, Małgorzata Korycka-Machała, Marcin Słomka, Jarosław Dziadek
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Online Access:	https://doi.org/10.1038/s41598-023-47944-6