Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins

The homologs EpCAM and TROP2, which both interact with claudin-1 and claudin-7, are frequently coexpressed in epithelia including skin. Intestine uniquely expresses high levels of EpCAM but not TROP2. We previously identified EpCAM as a substrate of the membrane-anchored protease matriptase and link...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chuan-Jin Wu, Michael Lu, Xu Feng, Gaku Nakato, Mark C. Udey
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	EpCAM TROP2 matriptase HAI-1 HAI-2 claudin
Online Access:	https://www.mdpi.com/2073-4409/9/4/1027