A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors. However, targeting EpCAM has been challenging because it is also highly expressed in normal...

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Bibliographic Details

Published in:	mAbs
Main Authors:	Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	Antibody engineering bispecific antibody conditionally active EpCAM protein engineering T-cell engager
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2322562