Directed brain connectivity biomarkers of healthy aging and Parkinson’s disease staging

IntroductionThe propagation of neural signals across various brain regions requires us to understand directional connectivity in functional magnetic resonance imaging (fMRI) data. We employ temporal partial directed coherence (TPDC), a data driven method to explore directional connectivity in young...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Tauqeer Anjum, Ali Seyfizadeh, Hao Ding, Tahir Mahmood, Rüdiger Pryss, Jens Volkmann, Dumitru Ciolac, Muthuraman Muthuraman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	fMRI directed connectivity Parkinson’s disease prodromal PD temporal partial directed coherence
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1698600/full