A First Metabolite Analysis of Norfolk Island Pine Resin and Its Hepatoprotective Potential to Alleviate Methotrexate (MTX)-Induced Hepatic Injury

Drug-induced liver injury (DILI) represents a significant clinical challenge characterized by hepatic dysfunction following exposure to diverse medications. Methotrexate (MTX) is a cornerstone in treating various cancers and autoimmune disorders. However, the clinical utility of MTX is overshadowed...

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出版年:	Pharmaceuticals
主要な著者:	Sherouk Hussein Sweilam, Dalia E. Ali, Ahmed M. Atwa, Ali M. Elgindy, Aya M. Mustafa, Manar M. Esmail, Mahmoud Abdelrahman Alkabbani, Mohamed Magdy Senna, Riham A. El-Shiekh
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2024-07-01
主題:	<i>Araucaria heterophylla</i> diterpenes IL-6/JAK/STAT3 pathway methotrexate-induced liver injury resin TGF-β/NF-κB signaling cascade
オンライン･アクセス:	https://www.mdpi.com/1424-8247/17/7/970