Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification

Abstract Introduction Microphysiological systems (MPS) offer simulation of (patho)physiological parameters. Investigation includes items which lead to fibrosis and calcification in development and progress of calcific aortic valve disease, based e.g. on culturing of isolated valvular interstitial ce...

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Bibliographic Details

Published in:	Journal of Biological Engineering
Main Authors:	Claudia Dittfeld, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems-Malte Tugtekin
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Calcific aortic valve disease Calcification Human valvular interstitial cells Hypoxia Dynamic cell culture Microphysiological system
Online Access:	https://doi.org/10.1186/s13036-024-00441-4