ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

Constitutive activation of the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway is crucial for tumor growth and progression. As such, this pathway has been an enticing target for drug discovery. Although HS-173 is a potent PI3K inhibitor that halts cancer cell proliferation via G2/M cell cycle...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chung-Pu Wu, Cheng-Yu Hung, Ya-Ju Hsieh, Megumi Murakami, Yang-Hui Huang, Tsung-Yao Su, Tai-Ho Hung, Jau-Song Yu, Yu-Shan Wu, Suresh V. Ambudkar
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	multidrug resistance ABCB1 ABCG2 PI3K HS-173
Online Access:	https://www.mdpi.com/2073-4409/12/7/1056