Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies

Abstract The diuretic drug hydrochlorothiazide (HCT) is associated with an increased risk of non-melanoma skin cancer upon UV exposure. The underlying cellular and molecular mechanisms behind this association remain elusive. Herein, a human skin model to assess the photocarcinogenic effects of HCT i...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Mathias Hohl, Felix Götzinger, Simone Jäger, Lea Wagmann, Mert Tokcan, Thomas Tschernig, Jörg Reichrath, Jan M. Federspiel, Peter Boor, Markus R. Meyer, Felix Mahfoud, Michael Böhm
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s42003-025-08064-1