Mechanisms of Substrate Recognition by the Multispecific Protein Lysine Methyltransferase SETD6

The SETD6 protein lysine methyltransferase monomethylates specific lysine residues in a diverse set of substrates which contain the target lysine residue in a highly variable amino acid sequence context. To investigate the mechanism underlying this multispecificity, we analyzed SETD6 substrate recog...

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Bibliographic Details

Published in:	Life
Main Authors:	Gizem T. Ulu, Sara Weirich, Jana Kehl, Thyagarajan T. Chandrasekaran, Franziska Dorscht, Dan Levy, Albert Jeltsch
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	SETD6 protein lysine methylation protein lysine methyltransferase enzyme specificity enzyme–substrate interaction
Online Access:	https://www.mdpi.com/2075-1729/15/10/1578