A split intein and split luciferase-coupled system for detecting protein-protein interactions

Abstract Elucidation of protein-protein interactions (PPIs) represents one of the most important methods in biomedical research. Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted much attention from both the academic and pharmaceutical sectors. We previo...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Zhong Yao, Jiyoon Kim, Betty Geng, Jinkun Chen, Victoria Wong, Anna Lyakisheva, Jamie Snider, Marina Rudan Dimlić, Sanda Raić, Igor Stagljar
Format:	Article
Language:	English
Published:	Springer Nature 2024-12-01
Subjects:	Protein-protein Interaction Tri-part Nanoluciferase Split Intein Inhibitor Drug Discovery
Online Access:	https://doi.org/10.1038/s44320-024-00081-2