Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro

Abstract DNA methylation plays a critical role in myelodysplastic syndrome (MDS). Here, we aimed to observe the effects of polydatin (PD) on DNA methylation in MDS cells on a genome-wide scale and explore the underlying mechanisms, providing new evidence for PD as a novel hypermethylation agent. We...

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出版年:	Scientific Reports
主要な著者:	Qingbing Zhou, Yuanbin Liang, Ruofan Chen, Hongzhi Wang, Qiuyue Guo, Li Liu, Xiaobo Zhu, Fengqin Xu
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2025-05-01
主題:	Myelodysplastic syndrome Polydatin Oncogene Hypermethylation Hypomethylation
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-01867-6