CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival

Chimeric antigen receptor (CAR) T cells have demonstrated outstanding therapeutic success in hematological malignancies. Yet, their efficacy against solid tumors remains constrained due to inadequate infiltration of cytotoxic T and CAR-T cells in the tumor microenvironment (TME), a factor correlated...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Siyue Nie, Yujie Song, Kun Hu, Wei Zu, Fengjiao Zhang, Lixia Chen, Qiang Ma, Zishan Zhou, Shunchang Jiao
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	CAR-T cells interleukin 15 CXCL10 infiltration Claudin18.2
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2024.2358590