Study of the effect of the VEGF receptor blockade on the antiischemic activity of the compound GK-2 in a rat hind limb ischemia model

Earlier, in experiments in vitro and in vivo, it was shown that the TrkA receptor agonist compound GK-2, which was a low molecular weight NGF mimetic, had pronounced angiogenic and antiischemic activity. However, it remained unclear whether this activity was associated with the activation of VEGF-A,...

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Bibliographic Details

Published in:	Фармакокинетика и Фармакодинамика
Main Authors:	E. S. Pekeldina, I. A. Miroshkina, A. V. Sorokina, N. M. Sazonova, M. B. Vititnova, S. A. Kryzhanovskiy
Format:	Article
Language:	Russian
Published:	LLC “Publisher OKI” 2022-02-01
Subjects:	trka receptor agonist – gk-2 compound trka receptor antagonist – gk-1 compound bevacizumab hind limb ischemia in rats antiischemic effect
Online Access:	https://www.pharmacokinetica.ru/jour/article/view/295