Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Small interfering RNAs (siRNAs) have potential to silence virtually any disease-causing gene but require chemical modifications for delivery to the tissue and cell of interest. Previously, we demonstrated that asymmetric, phosphorothioate (PS)-modified, chemically stabilized, cholesterol-conjugated...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Socheata Ly, Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Subjects:	siRNAs chemically modified siRNAs cholesterol conjugated siRNAs siRNA trafficking phosphorothioate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253120302183