Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease

Abstract Background E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspected to contribute to the multifactorial pathogenesis of CD, we studi...

Full description

Bibliographic Details

Published in:	Clinical Epigenetics
Main Authors:	Charles de Ponthaud, Solafah Abdalla, Marie-Pierre Belot, Xiaojian Shao, Christophe Penna, Antoine Brouquet, Pierre Bougnères
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Crohn disease CpG methylation E-cadherin
Online Access:	https://doi.org/10.1186/s13148-024-01631-z