M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion

Abstract: Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, b...

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发表在:Blood Advances
Main Authors: Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y. Lucy Liu, Michele H. Cottler-Fox, Peter D. Emanuel, Martin Hauer-Jensen, Irwin D. Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J. Murray, Daohong Zhou
格式: 文件
语言:英语
出版: Elsevier 2018-04-01
在线阅读:http://www.sciencedirect.com/science/article/pii/S2473952920310302