2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells

Summary: 2-Methylthio-N6-isopentenyl modification of adenosine (ms2i6A) is an evolutionally conserved modification found in mitochondrial (mt)-tRNAs. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1) specifically converts N6-isopentenyladenosine (i6A) to ms2i6A at position A37 of four mt-DNA-e...

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Bibliographic Details

Published in:	iScience
Main Authors:	Takahiro Yamamoto, Atsushi Fujimura, Fan-Yan Wei, Naoki Shinojima, Jun-ichiro Kuroda, Akitake Mukasa, Kazuhito Tomizawa
Format:	Article
Language:	English
Published:	Elsevier 2019-11-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004219303918