Delayed MSC therapy enhances resolution of organized pneumonia induced by antibiotic resistant Klebsiella pneumoniae infection

IntroductionMesenchymal stromal cells (MSC) are a promising therapeutic for pneumonia-induced sepsis. Here we sought to determine the efficacy of delayed administration of naïve and activated bone marrow (BM), adipose (AD), and umbilical cord (UC) derived MSCs in organized antibiotic resistant Klebs...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Declan Byrnes, Claire Masterson, Jack Brady, Shahd Horie, Sean D. McCarthy, Hector Gonzalez, Daniel O’Toole, John Laffey
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	mesenchymal stromal cells sepsis immune tolerance pneumonia fibrosis rodent animal models
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1132749/full