Dimethyloxalylglycine Suppresses SREBP1c and Lipogenic Gene Expressions in Hepatocytes Independently of HIF1A

Dimethyloxalylglycine (DMOG) is a representative inhibitor of the prolyl hydroxylase domain (PHD), which mediates the degradation of hypoxia-inducible factor-1-alpha (HIF1A). DMOG exerts its pharmacological effects via the canonical pathway that involves PHD inhibition; however, it remains unclear w...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Yong Seong Kwon, Ye Eun Cho, Yeonsoo Kim, Minseob Koh, Seonghwan Hwang
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	dimethyloxalylglycine prolyl hydroxylase domain hypoxia-inducible factor-1-alpha fatty liver fatty acid synthesis sterol regulatory element-binding protein-1c
Online Access:	https://www.mdpi.com/1467-3045/46/3/151