Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

Abstract Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent of glycolysis dependence in AML by focusing on the role of lactate dehydrogenase A (LDHA),...

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Bibliographic Details

Published in:	Cancer & Metabolism
Main Authors:	Ayşegül Erdem, Séléna Kaye, Francesco Caligiore, Manuel Johanns, Fleur Leguay, Jan Jacob Schuringa, Keisuke Ito, Guido Bommer, Nick van Gastel
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Cancer metabolism Acute myeloid leukemia Glycolysis Lactate dehydrogenase A Redox balance NAD+
Online Access:	https://doi.org/10.1186/s40170-025-00392-4