Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

The self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer’s disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multip...

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Bibliographic Details

Published in:	Cells
Main Authors:	Mahmoud B. Maina, Youssra K. Al-Hilaly, Gunasekhar Burra, Janet E. Rickard, Charles R. Harrington, Claude M. Wischik, Louise C. Serpell
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	Alzheimer’s disease tau dityrosine paired helical filaments oxidative stress
Online Access:	https://www.mdpi.com/2073-4409/10/3/703