Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

Malignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death and senescence. Senescent cells can be elimin...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Daméhan Tchelougou, Nicolas Malaquin, Guillaume B. Cardin, Jordan Desmul, Simon Turcotte, Francis Rodier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	senescence senescence-like Bcl2/BclxL inhibitors senolytic BRAFi MEKi
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1368711/full