IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Abstract Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datas...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	E. Koncina, M. Nurmik, V. I. Pozdeev, C. Gilson, M. Tsenkova, R. Begaj, S. Stang, A. Gaigneaux, C. Weindorfer, F. Rodriguez, M. Schmoetten, E. Klein, J. Karta, V. S. Atanasova, K. Grzyb, P. Ullmann, R. Halder, M. Hengstschläger, J. Graas, V. Augendre, Y. E. Karapetyan, L. Kerger, N. Zuegel, A. Skupin, S. Haan, J. Meiser, H. Dolznig, E. Letellier
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Online Access:	https://doi.org/10.1038/s41467-023-39953-w