Transient Inhibition of the Mediodorsal Thalamus During Early Adolescence Induces Hypofrontality and Social Memory Deficits in Young Adulthood

Background: Dysconnectivity between the mediodorsal thalamus (MD) and medial prefrontal cortex (mPFC) during adolescence is linked to developmental and psychiatric disorders, as well as social behavioral deficits. However, the precise mechanisms that underlie these impairments remain elusive. Method...

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Bibliographic Details

Published in:	Biological Psychiatry Global Open Science
Main Authors:	Sha-Sha Yang, Quansheng He, Xinyang Gu, Shoupei Liu, Wei Ke, Liang Chen, Bo Li, Yousheng Shu, Wen-Jun Gao
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Subjects:	Calcium imaging GABAergic interneurons Hypofrontality Mediodorsal thalamus Prefrontal cortex Social cognition deficits
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667174325000400