Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline

Abstract Multidrug-resistant tuberculosis (MDR-TB), defined as resistance to the first-line drugs isoniazid and rifampin, is a growing source of global mortality and threatens global control of tuberculosis disease. The diarylquinoline bedaquiline has recently emerged as a highly efficacious drug ag...

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發表在:	Nature Communications
Main Authors:	Boatema Ofori-Anyinam, Meagan Hamblin, Miranda L. Coldren, Barry Li, Gautam Mereddy, Mustafa Shaikh, Avi Shah, Courtney Grady, Navpreet Ranu, Sean Lu, Paul C. Blainey, Shuyi Ma, James J. Collins, Jason H. Yang
格式:	Article
語言:	英语
出版:	Nature Portfolio 2024-11-01
在線閱讀:	https://doi.org/10.1038/s41467-024-53933-8