The Effect of Alendronate on Osteoclastogenesis in Different Combinations of M-CSF and RANKL Growth Factors

Bisphosphonates (BPs) are compounds resembling the pyrophosphate structure. BPs bind the mineral component of bones. During the bone resorption by osteoclasts, nitrogen-containing BPs are released and internalized, causing an inhibition of the mevalonate pathway. As a consequence, osteoclasts are un...

Full description

Bibliographic Details

Published in:	Biomolecules
Main Authors:	Věra Hedvičáková, Radmila Žižková, Matěj Buzgo, Michala Rampichová, Eva Filová
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	alendronate M-CSF osteoclastogenesis RANKL
Online Access:	https://www.mdpi.com/2218-273X/11/3/438