CD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression

Abstract CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining immune homeostasis in multiple sclerosis (MS). Hence, we aimed to explore the therapeutic efficacy and safety of adoptive cell therapy (ACT) utilizing induced antigen-specific Tregs in an animal model of MS, that is,...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ting-Ting Yang, Pen-Ju Liu, Qing-Yu Sun, Ze-Yi Wang, Guo-Bin Yuan, Ze-Xin Fan, Lin Ma, Jian-Feng Lu, Bo-Yi Yuan, Wen-Long Zou, Li-Min Zhao, Qian Li, Guang-Zhi Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Subjects:	Multiple sclerosis Experimental autoimmune encephalomyelitis Antigen specific Regulatory T cells Adoptive cell therapy
Online Access:	https://doi.org/10.1038/s41598-024-56739-2