A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar.

For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. Antivenom dose-finding studies usually recruit too few patients (e.g. fewer than 20) relative to clinically significant event rates (e.g. 5%). Model based a...

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出版年:	PLoS Neglected Tropical Diseases
主要な著者:	James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2020-11-01
オンライン･アクセス:	https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008109&type=printable