Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice

Summary: Pre-clinical use of humanized mice transplanted with CD34+ hematopoietic stem and progenitor cells (HSPCs) is limited by insufficient engraftment with adult non-mobilized HSPCs. Here, we developed a novel immunodeficient mice based on NOD-SCID-Il2γc−/− (NSG) mice to support long-term engraf...

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Bibliographic Details

Published in:	iScience
Main Authors:	Chun I. Yu, Rick Maser, Florentina Marches, Jacques Banchereau, Karolina Palucka
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Immunology Molecular biology Stem cells research
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224004590