Strategy for drug repurposing in fibroadipogenic replacement during muscle wasting: application to duchenne muscular dystrophy

BackgroundUnderstanding the cell functionality during disease progression or drugs’ mechanism are major challenges for precision medicine. Predictive models describing biological phenotypes can be challenging to obtain, particularly in scenarios where sample availability is limited, such as in the c...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Izzy Matthews, Priyanka Mehra, Xavier Suárez-Calvet, Patricia Piñol-Jurado, Dan Cox, Vellia Justian, Ana Carrasco-Rozas, Zoe Laidler, Andrew Bowey, Paul Rushton, Susana López-Fernández, Jordi Díaz-Manera, Esther Fernández-Simón
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	muscle dystrophies fibro-adipogenic progenitor cells fibrosis adipogenesis sarcopenia cachexia
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1505697/full