Establishment, characterization, and genetic profiling of patient-derived osteosarcoma cells from a patient with retinoblastoma

Abstract Osteosarcoma is the most common malignant bone cancer in pediatric patients. Patients who respond poorly to chemotherapy experience worse clinical outcomes with a high mortality rate. The major challenge is the lack of effective drugs for these patients. To introduce new drugs for clinical...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Patcharawadee Thongkumkoon, Apiwat Sangphukieo, Siripong Tongjai, Pitiporn Noisagul, Surasak Sangkhathat, Wison Laochareonsuk, Rawikant Kamolphiwong, Piyaporn Budprom, Pimpisa Teeyakasem, Petlada Yongpitakwattana, Viraporn Thepbundit, Nutnicha Sirikaew, Jeerawan Klangjorhor, Jongkolnee Settakorn, Sutpirat Moonmuang, Pathacha Suksakit, Arnat Pasena, Jeerayut Chaijaruwanich, Wilawan Yathongkhum, Sivamoke Dissook, Dumnoensun Pruksakorn, Parunya Chaiyawat
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Subjects:	Primary cell culture Bone neoplasm Whole-genome sequencing Biological effects Cryopreservation
Online Access:	https://doi.org/10.1038/s41598-024-60628-z