Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats

Abstract Background Doxorubicin (DOX) is an effective antitumor agent, but its clinical usage is limited due to adverse cardiotoxic effects. Several compounds have been studied to reduce DOX cardiotoxicity to improve its therapeutic index. This study was aimed to investigate the protective effects o...

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Bibliographic Details
Published in:BMC Pharmacology and Toxicology
Main Authors: Maryam Shekari, Narges Khalilian Gortany, Mina Khalilzadeh, Alireza Abdollahi, Homanaz Ghafari, Ahmad Reza Dehpour, Mahmoud Ghazi-Khansari
Format: Article
Language:English
Published: BMC 2022-05-01
Subjects:
Doxorubicin
Sodium thiosulfate
Cardiotoxicity
Reactive oxygen species
Oxidative stress
Online Access:https://doi.org/10.1186/s40360-022-00569-3

Internet

https://doi.org/10.1186/s40360-022-00569-3

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