Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Hyeongmin Kim, Chung-Lyol Lee, Seohyun Lee, Tae Jin Lee, Iqra Haleem, Younghong Lee, Na Jung Hwang, Kyusun Shim, Dohyun Kim, Jaehwi Lee
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Subjects:	swelling gastroretentive system cogrinding technique freeze–thawing method β-lapachone dissolution behavior mechanical strength
Online Access:	https://www.mdpi.com/1999-4923/11/6/271