Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS

Variability in disease onset and progression is a hallmark of amyotrophic lateral sclerosis (ALS), both in sporadic and genetic forms. Recently, we found that SOD1-G93A transgenic mice expressing the same amount of mutant SOD1 but with different genetic backgrounds, C57BL/6JOlaHsd and 129S2/SvHsd, s...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Massimo Tortarolo, Andrea David Re Cecconi, Laura Camporeale, Cassandra Margotta, Giovanni Nardo, Laura Pasetto, Valentina Bonetto, Mariarita Galbiati, Valeria Crippa, Angelo Poletti, Rosanna Piccirillo, Caterina Bendotti
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Amyotrophic lateral sclerosis STAT3, muscle atrophy Sunitinib SOD1 Disease progression Atrogenes
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124001761