Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints, amongst which are a set of deubiquitinating protea...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Dharjath S. Hameed, Huib Ovaa, Gerbrand J. van der Heden van Noort, Aysegul Sapmaz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	ubiquitin cyclic peptide UCH-L5 peptide inhibitor deubiquitinase proteasome
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.866467/full