BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome

IntroductionPreeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear. MethodsHuman placenta samples were collected fr...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Man Zhao, Zexin Yang, Yan Kang, Zhenya Fang, Changqing Zhang, Chunying Wang, Meijuan Zhou, Junjun Guo, Anna Li, Meihua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Subjects:
preeclampsia
trophoblast
mitophagy
BNIP3
NLRP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530015/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530015/full

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