Selective interactions at pre-replication complexes categorize baseline and dormant origins

Abstract DNA synthesis in metazoans initiates within a select group of replication origins (baseline origins), whereas other (dormant) origins do not initiate replication despite recruiting apparently indistinguishable pre-replication complexes. Dormant origins are activated as backups when DNA synt...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Bhushan L. Thakur, Christophe E. Redon, Haiqing Fu, Robin Sebastian, Nana A. Kusi, Sophie Z. Zhuang, Lorinc S. Pongor, Vilhelm A. Bohr, Mirit I. Aladjem
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-59509-4