Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In addition to being a surrogate marker of defec...

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發表在:	Molecular Oncology
Main Authors:	Durga Prasad Cherukuri, Joshua L. Deignan, Kingshuk Das, Wayne W. Grody, Harvey Herschman
格式:	Article
語言:	英语
出版:	Wiley 2015-08-01
主題:	<i>mPGES-1</i> Dinucleotide repeat Microsatellite instability Colorectal cancer
在線閱讀:	https://doi.org/10.1016/j.molonc.2015.01.009