SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1/Notch-1/NF-κB signaling to improve neurological function after ischemic stroke

Reactive astrogliosis is a critical process in the development of ischemic stroke. However, the precise mechanism by which reactive astrogliosis changes the pathogenesis of ischemic stroke remains elusive. Sterile alpha and TIR motif-containing 1 protein (SARM1) plays a key role in axonal degenerati...

Full description

Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Yan Qiong Fu, Yu Zheng, Zhuo Li Li, Xin Yi Huang, Xiao Wan Wang, Mai Yin Cui, Yun Qi Zhang, Bing Rui Gao, Chan Zhang, Xiao Xiao Fan, Yong Jian, Bai Hui Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Subjects:	SARM1 Ischemic stroke Astrogliosis Neuroinflammation Jagged-1 Notch-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125000890