Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential

Heparanase, a member of the carbohydrate-active enzyme (CAZy) GH79 family, is an endo-β-glucuronidase capable of degrading the carbohydrate moiety of heparan sulphate proteoglycans, thus modulating and facilitating remodeling of the extracellular matrix. Heparanase activity is strongly associated wi...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang, Yujing Zhang, Xing Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	glycosaminoglycan (GAG) heparanase structure substrate recognition cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.926353/full