Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXRSummary

Background & Aims: Transcription factors regulate gene expression that orchestrates liver physiology. Many bind at distal enhancers and chromatin looping is required to activate their targets. Chromatin architecture has been linked to essential functions of the liver, including metabolism an...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Yi Hao, Lu Han, Anqi Wu, Irina M. Bochkis
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Transcriptional Regulation Bile Acid Metabolism Foxa2 Nuclear Receptors
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X23001881