Cinobufagin inhibits hepatocellular carcinoma EMT-like stemness via VEGF/VEGFR2 autocrine signaling

Abstract Purpose This study aimed to explore the role of the VEGFa/VEGFR2 autocrine pathway in cinobufagin-induced inhibition of hepatocellular carcinoma metastasis. Methods A CCK-8 assay was performed to assess cell viability. Scratch healing, Transwell, and sphere formation assays were used to mea...

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发表在:	Discover Oncology
Main Authors:	Mingjun Ye, Shujun Chen, Chen Lu, Yangpei Wu, Jiaming Tian, Anqi Han, Jimin Zhu, Baikun Li, Qinglin Li
格式:	文件
语言:	英语
出版:	Springer 2025-05-01
主题:	Cinobufagin Hepatocellular carcinoma Autocrine pathway VEGFa/VEGFR2 Experimental study
在线阅读:	https://doi.org/10.1007/s12672-025-02707-9