Dual targeting and bioresponsive nano-PROTAC induced precise and effective lung cancer therapy

Abstract Epigenetic regulation has emerged as a promising therapeutic strategy for lung cancer treatment, which can facilitate the antitumor responses by modulating epigenetic dysregulation of target proteins in lung cancer. The proteolysis-targeting chimera (PROTAC) reagent, dBET6 shows effective i...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Xiaoling Guan, Xiaowei Xu, Yiwen Tao, Xiaohua Deng, Linlong He, Zhongxiao Lin, Jishuo Chang, Jionghua Huang, Dazhi Zhou, Xiyong Yu, Minyan Wei, Lingmin Zhang
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	PROTAC dBET6 Dual targeting Bioresponsiveness Lung cancer
Online Access:	https://doi.org/10.1186/s12951-024-02967-7