Metformin Alleviates Pain States by Regulating the Balance of Spinal Synaptic Transmission

Background: Metformin has been shown to have potent analgesic effects; however, the underlying mechanism of synaptic plasticity mediating analgesia remained ambiguous. Methods: In this study, animal behavioral tests, whole-cell patch‑clamp recording, immunofluorescence staining, and network pharmaco...

Full description

Bibliographic Details

Published in:	Journal of Integrative Neuroscience
Main Authors:	Dongxia Duan, Xiaojin Wu, Usman Ali, Di Wang, Xue Li, Ruimei Liu, Le Ma, Yemeng Mao, Yan Ma
Format:	Article
Language:	English
Published:	IMR Press 2024-01-01
Subjects:	pain metformin mepscs c-fos glutamatergic transmission
Online Access:	https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301006