Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas

Abstract Background Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In...

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Bibliographic Details

Published in:	BMC Gastroenterology
Main Authors:	Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-o Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	SMOC1 Colorectal cancer Serrated lesion Traditional serrated adenoma
Online Access:	https://doi.org/10.1186/s12876-024-03175-1